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Department of Surgery

Prof. Edward K. Geissler, PhD

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Head of Experimental Surgery

January 31, 1960, in Chippewa Falls, Wisconsin, USA

1991 Ph.D. - Pathology and Laboratory Medicine (Biochemistry minor), University of Wisconsin-Madison, Wisconsin, USA
1984 Bachelor of Science - Medical Technology, University of Wisconsin-Eau Claire, Wisconsin, USA

09/2000 - present Professor, Head of Experimental Surgery, with tenure, Departement of Surgery, University Hospital Regensburg, University of Regensburg, Regensburg, Germany
1995-08/2000 Associate Professor/Assistant Professor
Department of Clinical Laboratory Sciences
University of South Alabama, Mobile, Alabama, USA
1991-1994 Postdoctoral Fellow
Department of Surgery and Transplantation
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA

Transplantation: Executive Editor, January 2015 - present
sponsored by The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS)
( http://www.transplantjournal.com/ )
Transplantation Direct: Executive Editor, January 2015 - present
sponsored by The Transplantation Society (TTS)
( http://www.transplantationdirect.com/ )
Transplantation Research: Editor-in-Chief, March 2011 - December 2014
BMC Journal( http://www.transplantationresearch.com/ )

Guest Editor
Current Opinion in Organ Transplantation: Section Editor 2014, January-December 2014, Cellular Transplantation
( http://journals.lww.com/co-transplantation/pages/default.aspx )

Editorial Board
Hepatobiliary & Pancreatic Diseases International (HBPD INT): Editorial Committee Member

2017 Anthony P. Monaco Award from The Transplantation Science Committee of the Transplantation Society (TTS) for the most outstanding translational publication for the SiLVER Study as the most cited article in Transplantation in 2016
2008 Deutscher Krebspreis for Translational Research (German Cancer Society)
1999 Mercator Guest Professorship Award (Deutsche Forschungsgemeinschaft)
1995 Ortho Biotech/American Society of Transplant Physicians Grant-in-Aid Award
1994 NIH Postdoctoral Individual National Research Service Award

American Society of Transplantation (AST)
The Transplantation Society (TTS)
European Society of Transplantation (ESOT)
European Liver and Intestinal Transplant Association (ELITA)
Deutsche Transplantationsgesellschaft (DTG)
American Society of Clinical Pathologists (ASCP)
MISOT Network - Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT)

Society Committee Member
virtual Global Transplantation Laboratory (vGVL) initiative supported by the Transplantation Science Committee of the Transplantation Society (TTS) in collaboration with The ONE Study to develop international standardized protocols for immunological and genetic monitoring of human transplant recipients (2014 - present)
The Transplantation Society Basic Science Committee Member (2013 - present)
ESOT Scientific Program Committee Member for 2015 meeting in Brussels, Belgium

Scientific Interests

  • Immune monitoring
  • Immunotherapy
  • Post-transplant malignancy
  • Molecular oncology
  • Transplantation immunology
  • Immuno-oncology
  • Solid organ transplantation
  • Cellular therapy
  • Immunology and tolerance
  • Tolerance induction strategies
  • Immunosuppressive therapies
  • Metabolomics in cancer

Research Projects
1. Study of immunologic tolerance in transplant recipients and in patients with autoimmune disorders.
2. Experimental study of immunosupression and cancer in transplant recipients.
3. Deutsche Forschungsgemeinschaft (DFG) project to analyze metastatic disease progression. Title: DFG - FOR2127 Research Group. Selection and Adaptation During Metastatic Cancer Progression. "Überwachung und Kontrolle metastasierender Tumorerkrankungen durch das angeborene Immunsystem." ( http://www.for2127.de )
4. EU FP7 Seventh Framework Programme to support translational research in cell-based immunotherapy.
Title: The ONE Study: "A Unified Approach to Evaluating Cellular Immunotherapy." ( http://www.onestudy.org/ )
5. Deutsche Forschungsgemeinschaft (DFG) project to investigate early molecular and cellular immunological events that determine long-term allograft success.
Title: DFG - KFO243 ELITE Project: "Early Immunological Determinants of Late Transplant Outcome." ( http://www-kfo.uni-regensburg.de/ )
6. Clinical study of cancer in transplant recipients.
Title: SiLVER Study: A Prospective Randomised, Open-Labeled, Trial Comparing Sirolimus-Containing Versus mTor-Inhibitor-Free Immunosupression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma. ( http://www.silver-study.org/ )
7. Regensburg Center for Interventional Immunology (RCI) - "Research Group Transplantation." Transplantation immunology projects focusing on the prevention of organ rejection using novel cell therapy techniques, plus minimization of immunosuppression and reduction of cancer recurrence after Transplantation. ( http://www.rcii.de )
8. European Union COST Program, Cost Action BM1305 "European Cooperation in Science and Technology: Action to focus and accelerate cell-based tolerance-inducing therapies. ( http://www.cost.eu/COST_Actions/bmbs/BM1305 )

Selected Publications Pdf-File (83 kB)

Teaching and Lecturing Experience
- Research in Experimental Surgery
- Laboratory Training for Research Personnel
- Journal Club and Workgroup Seminars in Experimental Surgery
- Methods in Transplantation Immunology
- Introductory and Advanced FACS Analysis
- Animals Models for Tumor Angiogenesis Research
- Microsurgery Operating Techniques
- Clinical and Laboratory Hematology
- Clinical Immunology and Bacteriology
- Pathophysiology
- Clinical Hematology/Coagulation Practicum
- Clinical Body Fluids and Urine Analysis Practicum

- Numerous basic immunologic assays
- Flow cytometry
- Western blotting
- Cloning
- Animal organ transplantation
- Tumor models
- Cell product manufacturing

Experimental Surgery and Transfusion Medicine Quality Control Laboratory
The Qualitätskontrolle (QK) facility is a Good Manufacturing Practice (GMP)-certified analytical laboratory shared between the Department of Surgery and Department of Transfusion Medicine. The QK lab is responsible for pharmaceutical release testing of transfusion products, such as thrombocytes, granulocytes, CD34+ haematopoietic stem cells and extracorporeal photopheresates. In addition, the QK lab performs a variety of standardised immune monitoring assays, which include comprehensive peripheral blood leucocyte phenotyping and tests of leucocyte function. As a service to clinical researchers at UKR, the QK lab performs its standard assays on request or to support clinical trials. Where sufficient demand exists, the QK lab will develop and validate new clinical assays in partnership with other research groups. Lab Head, Dr. James Hutchinson, Lab Supervisor, Dr. Katharina Kronenberg, Surgery Dept., Qualified Person, Dr. Norbert Ahrens, Lab Head, Dr. Viola Hähnel, Transfusion Medicine.

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