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Contact:
PD Dr. Simone Thomas
Department of Internal Medicine III
University Hospital Regensburg Franz-Josef-Strauß-Allee 11 93053 Regensburg Phone: +49-941 944-5142 Fax: 0941 944-5143 e-mail: simone.thomas@ukr.de
Group members
E-Mail: Tim.Steinberg@ukr.de
E-Mail: Michael.Zwerger@ukr.de
Current Projects:
The effects of IDH mutations on the interplay between metabolism and anti-leukemic immune response Involved members: Kathrin Hammon, Sebastian Klobuch Funding: Deutsche Forschungsgemeinschaft (KFO262)
Allogenic lymphocyte therapy: HLA-DP specific T cell receptors for adoptive immunotherapies against leukemias Involved members: Sarah Vatter, Michael Zwerger, Carina Mirbeth Funding: Regensburg Center for Interventional Immunology (RCI), Wilhelm-Sander Stiftung
Allogenic lymphocyte therapy: Development of bispecific soluble TCR molecules for CMV therapy Involved members: Maximilian Schmid, Mareile Siebörger Funding: Regensburg Center for Interventional Immunology (RCI)
Immunologic investigations about biomodulatory therapies of acute myeloid leukemias Involved members: Sebastian Klobuch, Tim Steinberg
Selected publications:
2017
Vatter S, Schmid M, Gebhard C, Mirbeth C, Klobuch S, Rehli M, Herr W, Thomas S. In-vitro blockade ot the CD4 co-signal in antigen-specific T-cell stimulation cultures induces the outgrowth of potent CD4 independent T-cell effectors. J Immunol Methods 2017 Nov 14. pii:S0022-1759(17)30420-9.doi: 10.1016/j.jim.2017.11.006. [Epub ahead of print]
Herr W, Eichinger Y, Beshay J, Bloetz A, Vatter S, Mirbeth C, Distler E, Hartwig UF, Thomas S. HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation. Leukemia 2016; 31:434
2016
Knies D, Klobuch S, Xue SA, Birtel M, Echchannaoui H, Yildiz O, Omokoko T, Guillaume P, Romero P, Stauss H, Sahin U, Herr W, Theobald M*, Thomas S*, Voss RH*. An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells. Oncotarget 2016; 7:21199 *shared senior authorship
Distler E, Albrecht J, Brunk A, Khan S, Schnürer E, Frey M, Mottok A, Jordán-Garrote AL, Brede C, Beilhack A, Mades A, Tomsitz D, Theobald M, Herr W*, Hartwig UF*. Patient-individualized CD8+ cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice. Int J Cancer. 2016; 138:1256.
2015
Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase MJ*, Herr W*, Lemmermann NA*. Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice. PLoS Pathogen. 2015; 11:e1005049. *shared last authorship
Zupke O, Distler E, Jürchott A, Paiphansiri U, Dass M, Thomas S, Hartwig U, Theobald M, Landfester K, Mailänder V, Herr W. Nanoparticles and antigen-specific T Cell Therapeutics: a Comprehensive Study on Uptake and Release. Nanomedicine 2015; 10:1063.
Thomas S, Schelker R, Klobuch S, Zaiss S, Troppmann M, Rehli M, Haferlach T, Herr W, Reichle A. Biomodulatory therapy induces complete molecular remission in chemorefractory acute myeloid leukemia. Haematologica 2015; 100:e4
2014
Thomas S, Klobuch S, Sommer M, van Ewijk R, Theobald M, Meyer RG, Herr W. Human CD8+ memory and EBV-specific T cells show low alloreactivity in vitro as well as in CD34+ stem-cell engrafted NOD/SCID/IL-2Rgcnull mice. Exp. Hematol. 2014; 42:28.
Teschner D, Distler E, Wehler D, Frey M, Marandiuc D, Langeveld K, Theobald M, Thomas S, Herr W. Depletion of naive T cells using clinical grade magnetic CD45RA beads: a new approach for GvHD prophylaxis. Bone Marrow Transplant. 2014; 49:138
2013
Sauer C*, Klobuch S*, Herr W, Thomas S**, Plachter B**. Subviral dense bodies of human cytomegalovirus stimulate maturation and activation of monocyte-derived immature dendritic cells. J Virol. 2013; 87: 11287-11291. *shared first authorship; **shared last authorship
2012
Thomas S, Klobuch S, Besold K, Plachter B, Dörrie J, Schaft N, Theobald M, Herr W. Strong and sustained effector function of memory- versus naive-derived T cells upon T-cell receptor RNA tranfer: Implications for cellular therapy. Eur. J. Immunol. 2012; 42:3442
Kleemann P, Distler E, Wagner EM, Thomas S, Klobuch S, Aue S, Schnürer E, Schild H, Theobald M, Plachter B, Tenzer S, Meyer RG, Herr W. Varicella-zoster virus glycoproteins B and E are major targets of CD4+ and CD8+ T cells reconstituting during zoster after allogeneic transplantation. Haematologica 2012; 97:874.
2011
Thomas S, Herr W. Natural and adoptive T-cell immunity against herpes family viruses after allogeneic hematopoietic stem cell transplantation. Immunotherapy. 2011; 3:771
Distler E, Bloetz A, Albrecht J, Asdufan S, Hohberger A, Frey M, Schnürer E, Thomas S, Theobald M, Hartwig UF, Herr W. Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells. Haematologica 2011; 96:1024.
2010
Voss RH*, Thomas S*, Pfirschke C, Hauptrock B, Kuball J, Grabowski M, Engel R, Guillaume P, Romero P, Huber C, Beckhove P, Theobald M. Coexpression of the T cell receptor constant alpha domain triggers tumor reactivity of single chain TCR transduced human T cells. Blood. 2010; 115:5154. *shared first authorship.