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Research Activities of the Laboratory for Mononuclear Phagocyte Biology – Epigenetics of Cell Differentiation

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Professor Dr. rer. nat. Michael Rehli
Klinik und Poliklinik für Innere Medizin III
Universitätsklinikum Regensburg
Franz-Josef-Strauss Allee 11
93042 Regensburg
Tel.: +49 (0)941 944 5587
Fax: +49 (0)941 944 5593
Laboratory: Tel.: +49 (0)941 944 5586, 5584, 5591

Lab meeting: Monday 8.30 am, Seminarraum Research Building H1

Web page: http://www.ag-rehli.de

Members of the AG Rehli:
(for e-Mail please type: first name.last name@ukr.de)
Dr. rer. nat Claudia Gebhard (Dipl. Biol.)
Dr. med. Daniel Heudobler (Arzt)
Julia Wegner (Dipl. Biochem.)
Sandra Schmidhofer (Dipl Biol.)
Sandra Pohl (M.Sc., B.Sc. Biochem.)
Julia Minderjahn (M.Sc., B.Sc. Biochem.)
Lucia Schwarzfischer (MTA)
Dagmar Glatz (MTA)
Johanna Raithel (MTA)
Ute Ackermann (MTA)

Research in the laboratory of Professor Dr. Michael Rehli focuses on two major topics. On one hand, they are studying mechanisms driving monocyte differentiation and how differentiation-dependent changes are controlled on the level of gene transcription. In this context, they are particularly interested in cell type-specific transcription factor binding and the establishment of cell type-specific chromatin structure, in particular at so-called enhancer elements. Epigenetic gene regulation by DNA methylation represents the second focus of research. Here, they are interested mechanisms driving disease-related alterations, active demethylation processes, as well as DNA methylation differences between individuals. For further information, please visit the lab web page at www.ag-rehli.de.

Publications AG Rehli:

Pham, T. H., Minderjahn, J., Schmidl, C., Hoffmeister, H., Schmidhofer, S., Chen, W., Langst, G., Benner, C., and Rehli, M. (2013) Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1, Nucleic Acids Research, in press.

Klug, M., Schmidhofer, S., Gebhard, C., Andreesen, R., and Rehli, M. (2013) 5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes, Genome Biology 14, R46.

Pham, T. H., Benner, C., Lichtinger, M., Schwarzfischer, L., Hu, Y., Andreesen, R., Chen, W., and Rehli, M. (2012) Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states, Blood 119, e161-171.

Hansmann, L., Schmidl, C., Kett, J., Steger, L., Andreesen, R., Hoffmann, P., Rehli, M., and Edinger, M. (2012) Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression, Journal of Immunology 188, 1275-1282.

Klug, M., Heinz, S., Gebhard, C., Schwarzfischer, L., Krause, S. W., Andreesen, R., and Rehli, M. (2010) Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels, Genome Biology 11, R63.

Gebhard, C., Benner, C., Ehrich, M., Schwarzfischer, L., Schilling, E., Klug, M., Dietmaier, W., Thiede, C., Holler, E., Andreesen, R., and Rehli, M. (2010) General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells, Cancer Research 70, 1398-1407.

Schmidl, C., Klug, M., Boeld, T. J., Andreesen, R., Hoffmann, P., Edinger, M., and Rehli, M. (2009) Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity, Genome Research 19, 1165-1174.

Schilling, E., El Chartouni, C., and Rehli, M. (2009) Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences, Genome Research 19, 2028-2035.

Korb, J., Weil, T., Hoffmann, K., Foster, K. R., and Rehli, M. (2009) A gene necessary for reproductive suppression in termites, Science 324, 758.

FANTOM Consortium. (2009) The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line, Nature Genetics 41, 553-562.



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