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2020

 

Yan Z, Yin H, Brochhausen C, Pfeifer CG, Alt V, Docheva D: Aged Tendon Stem/Progenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits. Front Bioeng Biotechnol. 2020 May 5;8:406 

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Hedderich J, El Bagdadi K, Angele P, Grässel S, Meurer A, Straub RH, Zaucke F, Jenei-Lanzl Z: Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation. Int J Mol Sci.  2020 May 30;21(11):3924

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Huber M, Schlosser D, Stenzel S, Maier J, Pattappa G, Kujat R, Striegl B, Docheva D: Quantitative Analysis of Surface Contouring with Pulsed Bipolar Radiofrequency on Thin Chondromalacic Cartilage. Biomed Res Int. 2020 Feb 27;2020:1242086.

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Strenzke M, Alberton P, Aszodi A, Docheva D, Haas E, Kammerlander C, Böcker W, Saller MM: Tenogenic Contribution to Skeletal Muscle Regeneration: The Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells Enhances Myogenic Differentiation In Vitro. Int J Mol Sci. 2020 Mar 13;21(6): E1965

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Riedl M, Witzmann C, Koch M, Lang S, Kerschbaum M, Baumann F, Krutsch W, Docheva D, Alt V, Pfeifer C; Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist. Int J Mol Sci. 2020 Feb 20;21(4):E1444. 

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Lin D, Alberton P, Delgado Caceres M, Prein C, Clausen-Schaumann H, Dong J, Aszodi A, Shukunami C, Iatridis JC, Docheva D; Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration. Aging Cell. 2020. Feb 21:e13091

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Yin H , Strunz FYan Z , Lu J, Brochhausen C, Kiderlen S , Clausen-Schaumann H , Wang X , Gomes ME , Alt V, Docheva D; Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells. Biomaterials. 2020;236:119802.

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Steinmann S, Pfeifer CG, Brochhausen C, Docheva D; Spectrum of Tendon Pathologies: Triggers, Trails and End-State.  Int J Mol Sci . 2020;21(3):E844.   

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2019

Steinmann S, Kunze P , Hampel C , Eckstein M , Bertram Bramsen J, Muenzner JK,  Carlé B, Ndreshkjana B,  Kemenes S,  Gasparini P,  Friedrich O, Andersen C,  Geppert C,  Wang S, Eyupoglu I, Bäuerle T,  Hartmann A,  Schneider-Stock R: DAPK1 loss triggers tumor invasion in colorectal tumor cells. Cell Death Dis. 2019;10(12):895. Published 2019 Nov 26

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Prager P, Schieker M, Jakob F, Docheva D, Konrads C, Steinert A; Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.  Biomed J . 2019;42(6):371–380  

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Janjic Rankovic M, Docheva D, Wichelhaus A, Baumert U; Effect of static compressive force on in vitro cultured PDL fibroblasts: monitoring of viability and gene expression over 6 days. Clin. Oral Investig. 2019. Nov. 

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Pattappa G, Schewior R, Hofmeister I, Seja J, Zellner J, Johnstone B, Docheva D, Angele P; Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis. Cells. 2019
Aug 20;8(8). 

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Alagboso FI, Budak M, Sommer U, Ray S, Kaiser A, Kampschulte M, Henss A, Dürselen L, Biehl C, Lips KS, Heiss C, Thormann U, Alt V; Establishment of a clinically relevant large animal model to assess the healing of metaphyseal bone. Eur Cell Mater. 2019 Jun 20;37:444-466

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Pattappa G, Zellner J, Johnstone B, Docheva D, Angele P; Cells under pressure - the relationship between hydrostatic pressure and mesenchymal stem cell chondrogenesis. Eur Cell Mater. 2019 May 6;37:360-381  

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Yin H, Caceres MD, Yan Z, Schieker M, Nerlich M, Docheva D; Tenomodulin regulates matrix remodeling of mouse tendon stem/progenitor cells in an ex vivo collagen I gel model. Biochem Biophys Res Commun. 2019 Mar 25 

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Koch M, Hammer S, Fuellerer J, Lang S, Pfeifer CG, Pattappa G, Weber J, Loibl M, Nerlich M, Angele P, Zellner J; Bone Marrow Aspirate Concentrate for the Treatment of Avascular Meniscus Tears in a One-Step Procedure—Evaluation of an In Vivo Model. Int. J. Mol. Sci. 2019, 20, 1120.

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Pfeifer CG, Karl A, Kerschbaum M, Berner A, Lang S, Schupfner R, Koch M, Angele P, Nerlich M, Mueller MB; TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation. Int J Stem Cells. 2019 Mar 30;12(1):139-150.

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Kiderlen S, Polzer C, Rädler JO, Docheva D, Clausen-Schaumann H, Sudhop S; Age-related changes in cell stiffness of tendon stem/progenitor cells and a rejuvenating effect of ROCK-inhibition. Biochem Biophys Res Commun. 2019 Feb 12;509(3): 839-844

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Pattappa G , Johnstone B, Zellner J, Docheva D, Angele P; The importance of physioxia in Mesenchymal Stem Cell chondrogenesis and the mechanisms controlling its response. Int J Mol Sci. 2019 Jan 23;20(3). pii: E484  

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2018

Grechenig S , Worlicek M, Penzkofer R, Zeman F, Kujat R, Heiss P, Pattappa G, Zellner J, Angele P; Bone block augmentation from the iliac crest for treatment of deep osteochondral defects of the knee resembles biomechanical properties of the subchondral. Knee Surg Sports Traumatol Arthrosc. 2018 Oct 28.

 

De Santis M, Di Matteo B, Chisari E, Cincinelli G, Angele P, Lattermann C, Filardo G, Vitale ND, Selmi C, Kon E; The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine. Biomed Res Int. 2018 Oct 15:7402947.

 

Janjic M, Docheva D, Trickovic Janjic O, Wichelhaus A, Baumert U; In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review. Stem Cells Int. 2018 Jul 31:3208285.
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Hsieh CF, Yan Z, Schumann RG, Milz S, Pfeifer CG, Schieker M, Docheva D; In Vitro Comparison of 2D-Cell Culture and 3D-Cell Sheets of Scleraxis-Programmed Bone Marrow Derived Mesenchymal Stem Cells to Primary Tendon Stem/Progenitor Cells for Tendon Repair. Int J Mol Sci. 2018 Aug 2;19(8).
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Delgado Caceres M , Pfeifer C, Docheva D; Understanding tendons: lessons from transgenic mouse models. Stem Cells Dev. 2018 Sep 1;27(17):1161-1174
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Yin H , Yan Z, Bauer RJ, Peng J, Schieker M, Nerlich M, Docheva D; Functionalized thermosensitive hydrogel combined with tendon stem/progenitor cells as injectable cell delivery carrier for tendon tissue engineering. Biomed Mater. 2018 Mar 16;13(3):034107.
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Yan Z , Yin H, Nerlich M, Pfeifer CG, Docheva D; Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers. J Exp Orthop. 2018 Jan 5;5(1):1.
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Schneider M, Angele P, Järvinen TAH, Docheva D; Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018 Apr;129:352-375.
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Weber J , Koch M, Angele P, Zellner J; The role of meniscal repair for prevention of early onset of osteoarthritis. J Exp Orthop. 2018 Apr 2;5(1):10
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Salzmann GM, Niemeyer P, Hochrein A, Stoddart MJ, Angele P; Articular Cartilage Repair of the Knee in Children and Adolescents. Orthop J Sports Med. 2018 Mar 13;6(3):2325967118760190
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Koch M, Mayr F, Achenbach L, Krutsch W, Lang S, Hilber F, Weber J, Pfeifer CG, Woehl R, Eichhorn J, Zellner J, Nerlich M, Angele P; Partial Anterior CruciateLigament Ruptures: Advantages by Intraligament Autologous Conditioned Plasma Injection and Healing Response Technique-Midterm Outcome Evaluation. Biomed Res Int. 2018 Jul 25:3204869
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Koch M, Matteo BD, Eichhorn J, Zellner J, Mayr F, Krutsch W, Achenbach L, Woehl R, Nerlich M, Angele P; Intra-ligamentary autologous conditioned plasma and healing response to treat partial ACL ruptures. Arch Orthop Trauma Surg. 2018 May;138(5):675-683

 

Koch M, Achatz FP, Lang S, Pfeifer CG, Pattappa G, Kujat R, Nerlich M, Angele P, Zellner J; Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells.  Stem Cells Int. 2018 May 7;2018:8207071.
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Frankewycz B , Penz A, Weber J, da Silva NP, Freimoser F, Bell R, Nerlich M, Jung EM, Docheva D, Pfeifer CG;   Achilles tendon elastic properties remain decreased in long term after rupture. Knee Surg Sports Traumatol Arthrosc. 2018 Jul;26(7):2080-2087.
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2017

Frankewycz B, Penz A, Weber J, da Silva NP, Freimoser F, Bell R, Nerlich M, Jung EM, Docheva D, Pfeifer CG; Achilles tendon elastic properties remain decreased in long term after rupture. Knee Surg Sports Traumatol Arthrosc. 2017 Nov 16.

 

Schneider M, Docheva D; Mysteries Behind the Cellular Content of Tendon Tissues. J Am Acad Orthop Surg. 2017 Dec;25(12):e289-e290.                                              

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Lin D, Alberton P, Caceres MD, Volkmer E, Schieker M, Docheva D; Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing. Cell Death Dis. 2017 Oct 12;8(10):e3116.                                                      

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Wu F, Nerlich M, Docheva D; Tendon injuries: Basic science and new repair proposals. EFORT Open Rev. 2017 Jul 27;2(7):332-342.

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Wertheimer C, Eibl-Lindner KH, Compera D, Kueres A, Wolf A, Docheva D, Priglinger SG, Priglinger C, Schumann RG; A cell culture technique for human epiretinal membranes to describe cell behavior and membrane contraction in vitro. Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2147-2155.

 

Kishimoto Y, Ohkawara B, Sakai T, Ito M, Masuda A, Ishiguro N, Shukunami C, Docheva D, Ohno K; Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells. PLoS One. 2017 Jul 27;12(7):e0182051.
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Leblanc DR, Schneider M, Angele P, Vollmer G, Docheva D; The effect of estrogen on tendon and ligament metabolism and function. J Steroid Biochem Mol Biol. 2017 Sep;172:106-116.
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Dex S, Alberton P, Willkomm L, Söllradl T, Bago S, Milz S, Shakibaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D; Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. EBioMedicine. 2017 Jun;20:240-254.                                               PDF

 

Ekwueme EC, Mohiuddin M, Yarborough JA, Brolinson PG, Docheva D, Fernandes HAM, Freeman JW; Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro. Clin Orthop Relat Res. 2017 Aug;475(8):2117-2127.

 

Koch M, Matteo BD, Eichhorn J, Zellner J, Mayr F, Krutsch W, Achenbach L, Woehl R, Nerlich M, Angele P; Intra-ligamentary autologous conditioned plasma and healing response to treat partial ACL ruptures. Arch Orthop Trauma Surg. 2018 Jan 30.

 

Zellner J, Pattappa G, Koch M, Lang S, Weber J, Pfeifer CG, Mueller MB, Kujat R, Nerlich M, Angele P; Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation? Stem Cells Res. Therap. 2017 10;8(1):225.                       PDF

 

Lang S, Herrmann M, Pfeifer C, Brockhoff G, Zellner J, Nerlich M, Angele P, Prantl L, Gehmert S, Loibl M; Leukocyte-reduced platelet-rich plasma stimulates the in vitro proliferation of adipose-tissue derived mesenchymal stem cells depending on PDGF signalling. Clin Hemorheol Microcirc. 2017;67(2):183-196.

 


Fickert S, Aurich M, Albrecht D, Angele P, Büchler L, Dienst M, Erggelet C, Fritz J, Gebhart C, Gollwitzer H, Kindler M, Lampert C, Madry H, Möckel G, Niemeyer P, Schröder J, Sobau C, Spahn G, Zinser W, Landgraeber S; Biologic Reconstruction of Full Sized Cartilage Defects of the Hip: A Guideline from the DGOU Group "Clinical Tissue Regeneration" and the Hip Committee of the AGA. Z Orthop Unfall. 2017 Dec;155(6):670-682.

 

Hilber F, Loibl M, Lang S, Kerschbaum M, Brockhoff G, Angele P, Zellner J, Schmitz P, Nerlich M, Worlicek M; Leukocyte-reduced platelet-rich plasma increases proliferation of tenocytes treated with prednisolone: a cell cycle analysis. Arch Orthop Trauma Surg. 2017 Oct;137(10):1417-1422.

 

Zellner J, Grechenig S, Pfeifer CG, Krutsch W, Koch M, Welsch G, Scherl M, Seitz J, Zeman F, Nerlich M, Angele P; Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined with Matrix-Guided Autologous Chondrocyte Transplantation. Am J Sports Med. 2017 Nov;45(13):3069-3080.

 

Koch M, Ehrenreich T, Koehl G, Pattappa G, Pfeifer C, Loibl M, Müller M, Nerlich M, Angele P, Zellner J; Do cell based tissue engineering products for meniscus regeneration influence vascularization? Clin Hemorheol Microcirc. 2017;67(2):125-140 .

 

Spahn G, Fritz J, Albrecht D, Angele P, Fickert S, Aurich M, Hofmann GO, Niemeyer P; Coincidence and Therapy of Dysalignments and Degenerative Knee Cartilage Lesions. Results from the German Cartilage Registry DGOU. Z Orthop Unfall. 2017 Aug;155(4):457-467.

 

Kreuz PC, Steinwachs M, Angele P; Single-dose local anesthetics exhibit a type-, dose-, and time-dependent chondrotoxic effect on chondrocytes and cartilage: a systematic review of the current literature. Knee Surg Sports Traumatol Arthrosc. 2017 Mar 13.

 

Pfeifer CG, Fisher MB, Saxena V, Kim M, Henning EA, Steinberg DA, Dodge GR, Mauck RL; Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model. Tissue Eng Part C Methods. 2017 Nov;23(11):745-753.

 

Frankewycz B, Krutsch W, Weber J, Ernstberger A, Nerlich M, Pfeifer CG; Rehabilitation of Achilles tendon ruptures: is early functional rehabilitation daily routine? Arch Orthop Trauma Surg. 2017 Mar;137(3):333-340.

 

Martin JT, Kim DH, Milby AH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL; In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model.  J Orthop Res. 2017Jan;35(1):23-31.  

 

2016

Hsieh CF, Alberton P, Loffredo-Verde E, Volkmer E, Pietschmann M, Müller PE, Schieker M, Docheva D; Periodontal ligament cells as alternative source for cell-based therapy of tendon injuries: in vivo study of full-size Achilles tendon defect in a rat model. Eur Cell Mater. 2016 Oct 20;32:228-240

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Pfeifer CG, Karl A, Berner A, Zellner J, Schmitz P, Loibl M, Koch M, Angele P, Nerlich M, Mueller MB; Expression of BMP and Actin Membrane Bound Inhibitor Is Increased during Terminal Differentiation of MSCs. Stem Cells Int. 2016;2016: 2685147

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Prantl L , Schreml J, Gehmert S, Klein S, Bai X, Zeitler K, Schreml S, Alt E, Gehmert S, Felthaus O; Transcription Profile in Sporadic Multiple Symmetric Lipomatosis Reveals Differential Expression at the Level of Adipose Tissue-Derived Stem Cells. Plast Reconstr Surg. 2016;137(4): 1181-90

 

Klein SM, Prantl L, Geis S, Felthaus O, Dolderer J, Anker A, Zeitler K , Alt E, Vykoukal J; Circulating serum CK level vs. muscle impairment for in situ monitoring burden of disease in Mdx-mice. Clin Hemorheol Microcirc. 2016

 

Di Matteo B, Loibl M, Andriolo L, Filardo G, Zellner J, Koch M, Angele P; Biologic agents for anterior cruciate ligament healing: A systematic review. World J Orthop. 2016 Sep 18;7(9):592-603

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Kuehlmann B, Prantl L ; Breast implants and possible association with ALCL: A retrospective study including a histological analysis of 296 explanted breast tissues and current literature. Clin Hemorheol Microcirc. 2016

 

Loibl M, Lang S, Hanke A, Herrmann M, Huber M, Brockhoff G, Klein S, Nerlich M, Angele P, Prantl L, Gehmert S; Leukocyte-Reduced Platelet-Rich Plasma Alters Protein Expression of Adipose Tissue-Derived Mesenchymal Stem Cells. Plast Reconstr Surg. 2016;138(2): 397-408

 

Loibl M, Lang S , Dendl LM, Nerlich M, Angele P, Gehmert S, Huber M; Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study. Biomed Res Int.; 2016

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Acklin YP, Zderic I, Buschbaum J, Varga P, Inzana JA, Grechenig S, Richards RG, Gueorguiev B, Schmitz P; Biomechanical comparison of plate and screw fixation in anterior pelvic ring fractures with low bone mineral density. Injury. 2016;47(7): 1456-60

 

Klein SM , Vykoukal J, Li DP, Pan HL, Zeitler K, Alt E, Geis S, Felthaus O, Prantl L; Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue-Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration-Approved Nerve Conduit. Plast Reconstr Surg. 2016;138(1): 132-9

 

Martin JT, Kim DH, Milby AH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL; In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model. J Orthop Res. 2016

 

Fisher MB, Belkin NS, Milby AH, Henning EA, Söegaard N, Kim M, Pfeifer C, Saxena V, Dodge GR, Burdick JA, Schaer TP, Steinberg DR, Mauck RL; Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model. Cartilage. 2016;7(2): 174-84

 

Hanke A, Prantl L, Wenzel C, Nerlich M, Brockhoff G, Loibl M, Gehmert S ; Semi-automated extraction and characterization of Stromal Vascular Fraction using a new medical device. Clin Hemorheol Microcirc. 2016

 

Loibl M, Lang S, Brockhoff G, Gueorguiev B, Hilber F, Worlicek M, Baumann F, Grechenig S, Zellner J, Huber M, Valderrabano V, Angele P, Nerlich M, Prantl L, Gehmert S; The effect of leukocyte-reduced platelet-rich plasma on the proliferation of autologous adipose-tissue derived mesenchymal stem cells1. Clin Hemorheol Microcirc. 2016;61(4): 599-614

 

Huber M, Loibl M, Eder C, Kujat R, Nerlich M, Gehmert S; Effects on the Distal Radioulnar Joint of Ablation of Triangular Fibrocartilage Complex Tears With Radiofrequency Energy. J Hand Surg [Am]. 2016;41(11): 1080-1086     


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