Eine Zusammenfassung der hier aufgeführten Publikationen sowie Informationen zum Autor bzw. den Autoren finden Sie auf den folgenden Seiten:
September 2020:
Ehrenschwender, M. et al.: NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and "osmotic reprogramming” in colorectal Cancer. In: Cell Death & Disease volume 11, Article number: 257 (2020).
doi:10.1038/s41419-020-2446-8
August 2020:
Yin H., Strunz F., Alt V., Docheva D. et al.: "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells.” Biomaterials. 2020 Apr;236:119802.
doi: 10.1016/j.biomaterials.2020.119802.
Juli 2020:
Geissler, Edward K. et al.: "Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A Trials"
https://doi.org/10.1016/S0140-6736(20)30167-7
Juni 2020:
Koller, M., Müller, K., Schulz, C. et al.: "Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field study" In: LANCET ONCOLOGY; Published online: March 23, 2020.
doi.org/10.1016/S1470-2045(20)30093-0
Mai 2020:
Riegel C., Hoffmann P., Edinger M. et al.: "Efficient teatment of murine acute GVHD by in vitro expanded donor regulatory T cells." In: Leukemia 34 (Nov 2019).
April 2020:
Delacher M., Feuerer M. et al.: Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. In: Immunity. 2020 Feb 18;52(2):295-312.
doi: 10.1016/j.immuni.2019.12.002
März 2020:
Niller, HH., Schmidt, B. et al.: Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation. In: Lancet Infect Dis . (Jan. 2020).
doi: 10.1016/S1473-3099(19)30546-8
Februar 2020:
Enhanced CaMKII-Dependent Late INa Induces Atrial Pro-Arrhythmic Activity in Patients with Sleep-Disordered Breathing. Simon Lebek, Konstantin Pichler, Kathrin Reuthner, Maximilian Trum, Maria Tafelmeier, Julian Mustroph, Daniele Camboni, Leopold Rupprecht, Christof Schmid, Lars S. Maier, Michael Arzt, Stefan Wagner. Circulation Research.
doi: 10.1161/CIRCRESAHA.119.315755
Dezember 2019:
Renner, K.; Bruss, C.; Schnell, A. et al.: "Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy." In: Cell Rep 29 (Oct 2019).
doi: 10.1016/j.celrep.2019.08.068
November 2019:
Heimer, S., Knoll, G., Schulze-Osthoff, K. et al.: "Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis." Cell Death Dis 10, 556 (2019)
Oktober 2019:
Dr. Arndt S., Prof. Dr. Karrer S., Prof. Dr. Hellerbrand C., Prof. Dr. Bosserhoff A. "Bone Morphogenetic Protein-6 Inhibits Fibrogenesis in Scleroderma Offering Treatment Options for Fibrotic Skin Disease." In: J Invest Dermatol. (März 2019).
doi: 10.1016/j.jid.2019.02.020.
September 2019:
Neubert, P. & Jantsch, J.: "HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting" Autophagy; Published online: April 14, 2019 In: Annals of Neurology (April 2019).
doi: org/10.1080/15548627.2019.159648
August 2019:
Strotzer, Q. et al.: Deep brain stimulation: Connectivity profile for bradykinesia alleviation. In: Annals of Neurology (April 2019).
doi: 10.1002/ana.25475
Juli 2019:
Schuster, P. et al.: Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. In: Front. Immunol. (Januar 2019).
doi: 10.3389/fimmu.2019.00002
Juni 2019:
Wege AK, O, Brockhoff G. et al.: "HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women." Breast Cancer Res. 2018 Nov 20;20(1):139.
doi: 10.1186/s13058-018-1072-1.
Mai 2019:
Pabel, S. et al.: "Empagliflozin directly improves diastolic function in human heart failure." European Journal of Heart Failure, Oct. 2018.
doi.org/10.1002/ejhf.1328
April 2019:
Poeppl TB, Donges MR, Mokros A, Rupprecht R, Fox PT, Laird AR, Bzdok D, Langguth B, Eickhoff SB.: "A view behind the mask of sanity: meta-analysis of aberrant brain activity in psychopaths." Molecular Psychiatryvolume 24, pages463–470 (2019).
DOI: https://doi.org/10.1038/s41380-018-0122-5
März 2019:
Paloma Riquelme, James A. Hutchinson et al.
"TIGIT + iTregs elicited by human regulatory macrophages control T cell immunity." Nature Communications Volume 9, Article Number: 2858 (2018).
doi.org/10.1093/cvr/cvy152
Februar 2019:
Sossalla, S. et al.
"Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart." Cardiovascular Research, Volume 114, Issue 13, 1 November 2018.
doi.org/10.1093/cvr/cvy152
Januar 2019:
Winkler, T.; Heid, I. et al.
"A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications." Nat Commun. 2018 May 16;9(1):1946.
doi: 10.1038/s41467-018-04124-9.
Dezember 2018:
Buchtler, S. et al.
"Cellular Origin and Functional Relevance of Collagen I Production in the Kidney". JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; Published online: May 18, 2018.
Doi: 10.1681/ASN.2018020138
November 2018:
Lebek, S. et al.
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity. J Mol Cell Cardiol. 2018; 118: 159-168;
Doi: 10.1016/j.yjmcc.2018.03.020
Mycielska, M. et al.
Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo. Cancer Res May 15 2018 78 (10) 2513-2523;
DOI: 10. 1158/0008-5472.CAN-17-2959
August 2018:
Zellner, J. et al.
Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation. Am J Sports Med. 2017 Nov;45(13):3069-3080.
doi: 10.1177/0363546517717679.
Juli 2018
Dr. med. Julian Mustroph & Dr. med. Stefan Neef
Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S.
"SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure” J Mol Cell Cardiol. 2018 Mar;116:81-90
https://doi.org/10.1016/j.yjmcc.2018.02.002
Juni 2018
M. Werner-Klein, S. Scheitler, M. Hoffmann et. al
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nature Communications 9, Article number: 595 (2018).
Doi: 10.1038/s41467-017-02674-y
Mai 2018
Neef, S. et al.
Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor
J Mol Cell Cardiol (2018) 115:73-81. doi:
https://doi.org/10.1016/j.yjmcc.2017.12.015
April 2018
Hoffmann M., Schamberger Th., et.al
Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer
International Journal of Cancer 2018, Vol. 142, Issue 4
https://doi.org/10.1002/ijc.31108
Januar 2018
Bittner S, Knoll G, Ehrenschwender M.,
Hyperosmotic stress enhances cytotoxicity of SMAC mimetics.
Cell Death & Disease. 2017;8(8):e2967-.
doi:10.1038/cddis.2017.355.
Dezember 2017
Can Martin Sag, Moritz Schnelle, Juqian Zhang, Colin E. Murdoch, Sabine Kossmann, Andrea Protti, Celio X. C. Santos, Greta J. Sawyer, Xiaohong Zhang, Heloise Mongue-Din, Daniel A. Richards, Alison C. Brewer, Oleksandra Prysyazhna, Lars S. Maier, Philip Wenzel, Philip J. Eaton, Ajay M. Shah
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell Nox2 on Blood Pressure
Circulation. 2017;CIRCULATIONAHA.116.023877
Published online: March 15, 2017
doi.org/10.1161/circulationaha.116.023877
November 2017
Koller M, Hjermstad MJ, Tomaszewski KA, Tomaszewska IM, Hornslien K, Harle A, Arraras JI, Morag O, Pompili C, Ioannidis G, Georgiou M, Navarra C, Chie WC, Johnson CD, Himpel A, Schulz C, Bohrer T, Janssens A, Kulis D, Bottomley A; EORTC Quality of Life Group; EORTC Lung Cancer Group; European Society of Thoracic Surgeons. An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients.
Ann Oncol. 2017 Aug 22. doi:
10.1093/annonc/mdx453. [Epub ahead of print] PubMed PMID: 28945875.
Oktober 2017
Neef, S. et al.
Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.
Basic Research in Cardiology (2017) 112: 45. doi:10.1007/s00395-017-0637-y
Scientific Reports 7:41521 DOI: 10.1038/srep41521
September 2017
Linda T. Betz, Andreas Mühlberger, Berthold Langguth & Martin Schecklmann
Stress Reactivity in Chronic Tinnitus
Scientific Reports 7:41521 DOI: 10.1038/srep41521
Wege AK, Weber F, Kroemer A, Ortmann O, Nimmerjahn F, Brockhoff G.
IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget. 2017 Jan 10;8(2):2731-2744.
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=13159&pubmed-linkout=1
Juni 2017
Bittner, S., Knoll, G. & Ehrenschwender, M.
Death receptor 3 mediates necroptotic cell death. Cellular and Molecular Life Sciences (2017) 74: 543. doi:10.1007/s00018-016-2355-2
https://link.springer.com/article/10.1007/s00018-016-2355-2#Abs1
Mai 2017
Hosseini H, Obradović MM, Hoffmann M, Harper KL, Sosa MS, Werner-Klein M, Nanduri LK1, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G, Gužvić M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf AD, Taran FA, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA3, Klein CA.
Early dissemination seeds metastasis in breast cancer.
Nature. 2016 Dec 14. doi: 10.1038/nature20785.
http://www.nature.com/nature/journal/v540/n7634/full/nature20785.html
April 2017
Almut Brand, Katrin Singer, Gudrun E. Koehl, Marlene Kolitzus, Gabriele Schoenhammer, Annette Thiel, Carina Matos, Christina Bruss, Sebastian Klobuch, Katrin Peter... Marina Kreutz.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Cell Metabolism 24 (November 8, 2016, 657–671). 2016 Elsevier Inc.
doi: 10.1016/j.cmet.2016.08.011
https://www.ncbi.nlm.nih.gov/pubmed/27641098
März 2017
Pylypenko O., Welz T., Tittel J., Kollmar M., Chardon F., Malherbe G., Weiss S., Michel C.I.L., Samol-Wolf A., Grasskamp A.T., Hume A., Goud B., Baron B., England P., Titus M.A., Schwille P., Weidemann T., Houdusse A., Kerkhoff E. (2016) Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. eLife 5:e17523
https://elifesciences.org/content/5/e17523
Februar 2017
W. Herr, Y. Eichinger, J. Beshay, A. Bloetz, S. Vatter, C. Mirbeth, E. Distler, U.F. Hartwig, S. Thomas
HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell Transplantation.
Leukemia. 2016 Sep 2. doi: 10.1038/leu.2016.210
http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2016210a.html
Januar 2017
Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R.
Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.
Microbiome. 2016;4:28. doi:10.1186/s40168-016-0175-0.
http://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0175-0
Dezember 2016
A. Benditz, M. Madl, M. Loher, J. Grifka, D. Boluki, O. Linhardt
Prospective medium-term results of multimodal pain management in patients with lumbar radiculopathy.
Sci. Rep. 6, 28187; doi: 10.1038/srep28187 (2016).
http://www.nature.com/articles/srep28187
November 2016
Knoll G, Bittner S, Kurz M, Jantsch J, Ehrenschwender M., Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy, Oncotarget (2016).
https://www.ncbi.nlm.nih.gov/pubmed/27166192
Oktober 2016
Kesselring et al., IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3, Cancer Cell (2016) http://dx.doi.org/10.1016/j.ccell.2016.03.014
September 2016
Schiechl G, Hermann FJ, Rodriguez Gomez M, Kutzi S, Schmidbauer K, Talke Y, Neumayer S, Goebel N, Renner K, Brühl H, Karasuyama H, Obata-Ninomiya K, Utpatel K, Evert M, Hirt SW, Geissler EK, Fichtner-Feigl S, Mack M.
Basophils trigger fibroblast activation in cardiac allograft fibrosis development.
Am J Transplant. 2016, Mar 1
doi: 10.1111/ajt.13764
August 2016
Probst T., Pryss R., Langguth B., Schlee W.
Emotional states as mediators between tinnitus loudness and tinnitus distress in daily life: Results from the "TrackYourTinnitus” application
Scientific Reports 6, (2016).
doi:10.1038/srep20382
Juli 2016
Fritsche, L.G., Igl, W., Cooke Bailey, J.N., Grassman, F., Sengupta, S., Bragg-Gresham, J.L., Weber, B.,..., Heid, I.M. (2015)
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
Nature Genetics. Advance online publication.
doi:10.1038/ng.3448
Juni 2016
I Siegert, J Schödel, M Nairz, V Schatz, K Dettmer, Ch Dick, J Kalucka, K Franke, M Ehrenschwender, G Schley, A Beneke, J Sutter, M Moll, C Hellerbrand, B Wielockx, D M Katschinski, R Lang, B Galy, M W. Hentze, P Koivunen, P J Oefner, Ch Bogdan, G Weiss, C Willam, J Jantsch
Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen
Cell Reports, vol 13, Issue 10 , p2048–2055.
Mai 2016
Eggenhofer E., Sabet-Rashedi M., Lantow M., Renner P., Rovira J., Koehl G.E., Schlitt H.J., Geissler E.K., Kroemer A.
RORyt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice
In: Journal of Hepatology, Volume 64, Issue 1, P. 128–134.
April 2016
Riemenschneider MJ, Hirblinger M, Vollmann-Zwerenz A, Hau P, Proescholdt MA, Jaschinski F, Rothhammer-Hampl T, Wosikowski K, Janicot M, Leo E (2015)
TGF-ß isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity. Oncotarget; 6: 26770-81.
März 2016
Inadequate glucocorticoid secretion in rat arthritis is accompanied by impaired mitochondria and altered lipid breakdown in the adrenal cortex.
In: Ann Rheum Dis 2015;74:1890-1897
Wolff C, Krinner K, Schröder JA, Straub RH
Februar 2016
Low urinary indoxyl sulfate levels early after ASCT reflect a disrupted microbiome and are associated with poor outcome.
In: Blood. 2015 Oct 1;126(14):1723-8.
Daniela Weber, Peter J. Oefner, Andreas Hiergeist, Josef Koestler, André Gessner, Markus Weber, Joachim Hahn, Daniel Wolff, Frank Stämmler, Rainer Spang, Wolfgang Herr, Katja Dettmer, and Ernst Holler
Januar 2016
IL-3 contributes to development of lupus nephritis in MRL / lpr mice In: Kidney International (2015) 88, 1088–1098; doi:10.1038/ki.2015.196
K. Renner, F. J. Hermann, K. Schmidbauer, Y. Talke, M. Rodriguez Gomez, G. Schiechl, J. Schlossmann, H. Brühl, H.-J. Anders, M. Mack
Dezember 2015
Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability.
In: Biomaterials 2015; 56:114-28.
Gallorini M, Petzel C, Bolay C, Hiller KA, Cataldi A, Buchalla W, Krifka S, Schweikl H.
November 2015
Sleep disordered breathing and enlargement of the right heart after myocardial infarction.
In: Eur Respir J. 2015 Mar;45(3):680-90. doi: 10.1183/09031936.00057014. Epub 2014 Oct 30. IF 7.125
Buchner S, Eglseer M, Debl K, Hetzenecker A, Luchner A, Husser O, Stroszczynski C, Hamer OW, Fellner C, Zeman F, Pfeifer M, Arzt M.
Oktober 2015
Bestrophin 1 is indispensable for volume Regulation in human retinal Pigment Epithelium cells
In: Proc Natl Acad Sci USA 112: E2630-E2639, 2015
Milenkovic A, Brandl C, Milenkovic VM, Jendryke T, Sirianant L, Wanitchakool P, Zimmermann S, Reiff CM, Horling F, Schrewe H, Schreiber R, Kunzelmann K, Wetzel CH, Weber BH
September 2015
Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function.
In: Nucleic Acids Research 2015, volume 43, 3524-3545
doi: 10.1093/narlgkv188
S. Pinz, S. Unser, D. Buob, P. Fischer, B. Jobst, A. Rascle
August 2015
XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis.
In: Cell Death and Disease (2014) 5, e1570;
doi: 10.1038/cddis.2014.534. Published online 11 December 2014.
M. Ehrenschwender, S. Bittner, K. Seibold, H. Wajant
Juli 2015
The ACDC Pilot Trial: Targeting the Anterior Cingulate by Double Cone Coil rTMS for the treatment of Depression.
In: Brain Stimulation, Volume 8, Issue 2, March–April 2015,
240–246.
Peter M. Kreuzer, Martin Schecklmann, Astrid Lehner, Thomas C. Wetter, Timm B. Poeppl, Rainer Rupprecht, Dirk de Ridder, Michael Landgrebe, Berthold Langguth
Juni 2015
CT Features of Early Type II Endoleaks after Endovascular Repair of Abdominal Aortic Aneurysms Help Predict Aneurysm Sac Enlargement.
In: Radiology. 2015 Mar;274(3):906-16
Müller-Wille R, Schötz S, Zeman F, Uller W, Güntner O, Pfister K, Kasprzak P, Stroszczynski C, Wohlgemuth WA.
Mai 2015
Prognosis according to histochemical analysis of liver metastases removed at liver resection.
Brunner SM, Kesselring R, Rubner C, Martin M, Jeiter T, Boerner T, Ruemmele P, Schlitt HJ, Fichtner-Feigl S.
April 2015
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII.
Stefan Wagner, Christian Dantz, Hannah Flebbe, Azadeh Azizian, Can Martin Sag, Susanne Engels, Johanna Möllencamp, Nataliya Dybkova, Towhidul Islam, Ajay M. Shah, Lars S. Maier. J Mol Cell Cardiol. 2014; 75: 206–215
März 2015
Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis.
Jenei-Lanzl Z, Capellino S, Kees F, Fleck M, Lowin T, Straub RH.
Ann Rheum Dis. 2015;74:444-451
Februar 2015
Decline in hepatitis E virus antibody prevalence in southeastern Germany, 1996-2011.
Jürgen J. Wenzel, Mathias Sichler, Mathias Schemmerer, Gundula Behrens, Michael F. Leitzmann, Wolfgang Jilg.
Hepatology. Oktober 2014, 60(4), 1180-1186. doi: 10.1002/hep.27244.
Januar 2015
Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections.
Amy J. Managh, Robert W. Hutchinson, Paloma Riquelme, Christiane Broichhausen, Anja K. Wege, Uwe Ritter, Norbert Ahrens, Gudrun E. Koehl, Lisa Walter, Christian Florian, Hans J. Schlitt, Helen J. Reid, Edward K. Geissler, Barry L. Sharp, James A. Hutchinson
The Journal of Immunology, September 2014, 193/5, 2600-2608.
August 2017
Poeppl TB, Langguth B, Rupprecht R, Safron A, Bzdok D, Laird AR, Eickhoff SB. The neural basis of sex differences in sexual behavior: A quantitative meta-analysis. Front Neuroendocrinol 2016;43:28–43.
Poeppl TB, Langguth B, Rupprecht R, Laird AR, Eickhoff SB. A neural circuit encoding sexual preference in humans. Neurosci Biobehav Rev 2016;68:530–6.
