Glanzlichter biomedizinischer Forschung

März 2023

Mathias Schemmerer, Jürgen J Wenzel, Klaus Stark, Mirko Faber. Molecular epidemiology and genotype-specific disease severity of hepatitis E virus infections in Germany, 2010-2019.

doi: 10.1080/22221751.2022.2091479

Februar 2023:

Blazquez et al. Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain. Oncogene, 2022.

doi: https://doi.org/10.1038/s41388-022-02496-3

Januar 2023:

Michael Paulus, Kathrin Renner, Alexander Nickel, Christoph Brochhausen, Katharina Limm, Elmar Zügner, Maria Baier, Steffen Pabel, Stefan Wallner, Christoph Birner, Andreas Luchner, Christoph Magnes, Peter Oefner, Klaus Stark, Stefan Wagner, Christoph Maack, Lars Maier, Katrin Streckfuss-Bömeke, Samuel Sossalla, Alexander Dietl. Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. Basic Research in Cardiology, 2022 Sep 6.

doi: 10.1007/s00395-022-00949-0

Dezember 2022:

Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab. Front Immunol. 13, 966236 Aug 24, 2022 ª 2022, Clara Luzia Magnus, Andreas Hiergeist, Philipp Schuster, Anette Rohrhofer, Jan Medenbach, André Gessner, David Peterhoff, Barbara Schmidt

doi: 10.3389/fimmu.2022.966236

November 2022:

Simon Lebek*, Philipp Hegner*, Rosa Hultsch, Jonas Rohde, Leopold Rupprecht, Christof Schmid, Samuel Sossalla, Lars Siegfried Maier, Michael Arzt, Stefan Wagner. Na_V1.8 dysregulates Na and Ca leading to arrhythmias in patients with sleep-disordered breathing. American Journal of Respiratory and Critical Care Medicine, 2022 Aug 9.

*geteilte Erstautorenschaft

doi: doi.org/10.1164/rccm.202205-0981LE

Oktober 2022:

Peter J.Siska,Jing Jiao,Carina Matos, Katrin Singer,Raffaela S.Berger,Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnII, Kristen N.Oliff, Benjamin J. Wilkins, Lanette M.Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H.Levine,Ines Ugele,Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo, eBIOMedicine. Part of The Lancet, Volume 74, December 2021, 103734.

doi:  doi.org/10.1016/j.ebiom.2021.103734

September 2022:

Förch A, Wallner S, Zeman F, Ettl T, Brochhausen C, Schreml S. Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors. Cells. 2022; 11(1):27.

doi: doi.org/10.3390/cells11010027

August 2022:

Animal experimental investigation on the efficacy of antibiotic therapy with linezolid, vancomycin, cotrimoxazole, and rifampin in treatment of periprosthetic knee joint infections by MRSA J. Goetz, V. Keyssner, F. Hanses, F. Greimel, F. Leiß, T. Schwarz, H-R. Springorum, J. Grifka, J. Schaumburger. Bone Joint Res. 2022 Mar;11(3):143-151.

doi: doi.org/10.1302/2046-3758.113.BJR-2021-0268.R1

Juli 2022:

Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel CH (2022) Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. Molecular Psychiatry.

doi: https://doi.org/10.1038/s41380-022-01660-1

Juni 2022:

Kirschneck C, Straßmair N, Cieplik F, et al. Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement. Biomedicines. 2021 Jul 8;9(7):796.

doi: 10.3390/biomedicines9070796

Mai 2022:

Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A. Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer, Lars S. Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla. Detrimental proarrhythmogenic interaction of Ca²⁺/calmodulin-dependent protein kinase II and Na_V1.8 in heart failure. Nat Commun 12, 6586 (2021).

doi: 10.1038/s41467-021-26690-1

April 2022:

Bernhard Neumann; Klemens Angstwurm, Ralf A. Linker, Gertrud Knoll, Lisa Eidenschink, Dennis Rubbenstroth, Kore Schlottau, Martin Beer, Patrick Schreiner, Erwin Soutschek, Merle M. Böhmer, Benedikt M.J. Lampl, Matthias Pregler, Alexander Scheiter, Katja Evert, Saida Zoubaa, Markus J. Riemenschneider, Benedikt Asbach, André Gessner, Hans Helmut Niller, Barbara Schmidt, Markus Bauswein. Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections.

doi: 10.1016/j.xcrm.2021.100499

März 2022:

Peter J. Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, Jana Klitzke, Marian Schön, Jakob Simeth, Josef Köstler, Heiko Siegmund, Ines Ugele, Michael Paulus, Alexander Dietl, Kristina Kolodova, Louisa Steines, Katharina Freitag, Alice Peuker, Gabriele Schönhammer, Johanna Raithel, Bernhard Graf, Florian Geismann, Matthias Lubnow, Matthias Mack, Peter Hau, Christopher Bohr, Ralph Burkhardt, Andre Gessner, Bernd Salzberger, Ralf Wagner, Frank Hanses, Florian Hitzenbichler, Daniel Heudobler, Florian Lüke, Tobias Pukrop, Wolfgang Herr, Daniel Wolff, Rainer Spang, Hendrik Poeck, Petra Hoffmann, Jonathan Jantsch, Christoph Brochhausen, Dirk Lunz, Michael Rehli, Marina Kreutz, and Kathrin Renner^. Published in Volume 131, Issue 22 on November 15, 2021  J Clin Invest. 2021;131(22):e148225.

doi: 10.1172/JCI148225

Februar 2022:

Xiaojun Mao, Nicholas S. Jakubovics, Maria Bächle, Wolfgang Buchalla, Karl-Anton Hiller, Tim Maisch, Elmar Hellwig, Christian Kirschneck, André Gessner, Ali Al-Ahmad & Fabian Cieplik (2021) Colonization of Helicobacter pylori in the oral cavity – an endless controversy?, Critical Reviews in Microbiology, 47:5, 612-629.

doi: 10.1080/1040841X.2021.1907740

Januar 2022:

Meedt E, Hiergeist A, Gessner A, et al. Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation. Clin Infect Dis. Published online May 27, 2021:ciab500.

doi: 10.1093/cid/ciab500

Dezember 2021:

Tafelmeier M, Luft L, Zistler E, Floerchinger B, Camboni D, Creutzenberg M, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M. Central Sleep Apnea Predicts Pulmonary Complications After Cardiac Surgery. Chest. 2021 Feb;159(2):798-809.

doi: 10.1016/j.chest.2020.07.080

November 2021:

Renner, K., Schwittay, T., Chaabane, S. et al. Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes. Nat Commun. 2021 May 21;12(1):3006

doi: https://doi.org/10.1038/s41467-021-23334-2 

Oktober 2021:

Julian Mustroph, Can M. Sag, Felix Bähr, Anna-Lena Schmidtmann, Shamindra N. Gupta, Alexander Dietz, M.M. Towhidul Islam, Charlotte Lücht, Bo Eric Beuthner, Steffen Pabel, Maria J. Baier, Ali El-Armouche, Samuel Sossalla, Mark E. Anderson, Julia Möllmann, Michael Lehrke, Nikolaus Marx, Peter J. Mohler, Donald M. Bers, Bernhard Unsöld, Tao He, Matthias Dewenter, Johannes Backs, Lars S. Maier, Stefan Wagner. Loss of CASK Accelerates Heart Failure Development, Circulation Research. 2021;128:1139–1155.

doi: https://doi.org/10.1161/CIRCRESAHA.120.318170

September 2021:

Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastian Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet and Philipp Beckhove. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. Nat Commun 12, 1119 (2021). 

doi: https://doi.org/10.1038/s41467-021-21297-y

August 2021:

Zhang J. , Byers P. , Erben A. , Frank C. , Schulte-Spechtel L. , Heymann M. , Docheva D. , Huber H. , Sudhop S. , Clausen-Schaumann H. "Single Cell Bioprinting with Ultrashort Laser Pulses" Advanced Functional Materials. 2021 Mar 26

doi: https://doi.org/10.1002/adfm.202100066

Juli 2021:

Delacher M, Simon S, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Schmidleithner L, Bittner S, Pant A, Ritter U, Hehlgans T, Riegel D, Schneider V, Groeber-Becker FK, Eigenberger A, Gebhard C, Strieder N, Fischer A, Rehli R, Hoffmann P, Edinger M, Strowig T, Huehn J, Schmidl C, Werner JM, Prantl L, B Brors B, Imbusch CD, Feuerer M. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity , 2021

doi: https://www.sciencedirect.com/science/article/pii/S1074761321001199?via%3Dihub

Juni 2021:

Haderer M, Neubert P, Rinner E, Scholtis A, Broncy L, Gschwendtner H, Kandulski A, Pavel V, Mehrl A, Brochhausen C, Schlosser S, Gülow K, Kunst C, Müller M. Novel pathomechanism for spontaneous bacterial peritonitis: Disruption of cell junctions by cellular and bacterial proteases. Gut 2021.

doi: https://doi.org/10.1136/gutjnl-2020-321663

Mai 2021:

Haferkamp, S, Hutchinson, J A et al.: "Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis." Nat Commun 12, 1439 (2021).

doi: https://doi.org/10.1038/s41467-021-21572-y

April 2021:

Hansen, Ernil et al.: "Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial." BMJ 2020 Dec 10; 371:m4284.

doi:  https://doi.org/10.1136/bmj.m4284

Editorial: Boet, S & McIsaac, DI: "Can We Sooth the Subconscious during General Anaesthesia?" BMJ 2020 Dec 10; 371:m4547.

doi: https://doi.org/10.1136/bmj.m4547

März 2021:

Corbacioglu, Selim et al.: "CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia" in: N Engl J Med. 2020, Dec 5.

doi: 10.1056/NEJMoa2031054 

Februar 2021:

Werner-Klein, Melanie et al.: "Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency" in: Nature Communications 2020, Oct. 2020.

doi: https://doi.org/10.1038/s41467-020-18701-4

Januar 2021:

Kerkhoff, Eugen et al.: "Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins" in Nat Commun. Published: July 13, 2020.

doi: 10.1038/s41467-020-17212-6

November 2020:

Neubert, Patrick; Schröder, Agnes; Jantsch, Jonathan et al.: "NCX1 represents an ionic Na+ sensing mechanism in macrophages" in: PLOS BIOLOGY, June 22, 2020.

https://doi.org/10.1371/journal.pbio.3000722

Oktober 2020:

Schröder, Agnes; Kirschneck, Christian; Jantsch, Jonathan et al.: "Osteoprotective action of low-salt diet requires myeloid cell-derived NFATS" In: Volume 4, Issue 23 on December 5, 2019 JCI Insight. 2019;4(23):e127868.

https://doi.org/10.1172/jci.insight.127868

September 2020:

Ehrenschwender, M. et al.: NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and "osmotic reprogramming” in colorectal Cancer. In: Cell Death & Disease volume 11, Article number: 257 (2020).

doi:10.1038/s41419-020-2446-8

August 2020:

Yin H., Strunz F., Alt V., Docheva D. et al.: "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells.” Biomaterials. 2020 Apr;236:119802.

doi: 10.1016/j.biomaterials.2020.119802.

Juli 2020:

Geissler, Edward K. et al.: "Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A Trials"

https://doi.org/10.1016/S0140-6736(20)30167-7

Juni 2020:

Koller, M., Müller, K., Schulz, C. et al.: "Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field study" In: LANCET ONCOLOGY; Published online: March 23, 2020.

doi.org/10.1016/S1470-2045(20)30093-0

Mai 2020:

Riegel C., Hoffmann P., Edinger M. et al.: "Efficient teatment of murine acute GVHD by in vitro expanded donor regulatory T cells." In: Leukemia 34 (Nov 2019).

doi:10.1038/s41375-019-0625-3

April 2020:

Delacher M., Feuerer M. et al.: Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. In: Immunity. 2020 Feb 18;52(2):295-312.

doi: 10.1016/j.immuni.2019.12.002

März 2020:

Niller, HH., Schmidt, B. et al.: Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation. In: Lancet Infect Dis . (Jan. 2020).

doi: 10.1016/S1473-3099(19)30546-8

Februar 2020: 

Enhanced CaMKII-Dependent Late INa Induces Atrial Pro-Arrhythmic Activity in Patients with Sleep-Disordered Breathing. Simon Lebek, Konstantin Pichler, Kathrin Reuthner, Maximilian Trum, Maria Tafelmeier, Julian Mustroph, Daniele Camboni, Leopold Rupprecht, Christof Schmid, Lars S. Maier, Michael Arzt, Stefan Wagner. Circulation Research.

  
doi: 10.1161/CIRCRESAHA.119.315755

Dezember 2019:

Renner, K.; Bruss, C.; Schnell, A. et al.: "Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy." In: Cell Rep 29 (Oct 2019).

doi: 10.1016/j.celrep.2019.08.068

November 2019:

Heimer, S., Knoll, G., Schulze-Osthoff, K. et al.: "Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis." Cell Death Dis 10, 556 (2019)

doi:10.1038/s41419-019-1790-z 

Oktober 2019:

Dr. Arndt S., Prof. Dr. Karrer S., Prof. Dr. Hellerbrand C., Prof. Dr. Bosserhoff A. "Bone Morphogenetic Protein-6 Inhibits Fibrogenesis in Scleroderma Offering Treatment Options for Fibrotic Skin Disease." In: J Invest Dermatol. (März 2019).

doi: 10.1016/j.jid.2019.02.020.

September 2019:

Neubert, P. & Jantsch, J.: "HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting" Autophagy; Published online: April 14, 2019 In: Annals of Neurology (April 2019).

doi: org/10.1080/15548627.2019.159648

August 2019:

Strotzer, Q. et al.: Deep brain stimulation: Connectivity profile for bradykinesia alleviation. In: Annals of Neurology (April 2019).

doi: 10.1002/ana.25475

Juli 2019:

Schuster, P. et al.: Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. In: Front. Immunol. (Januar 2019).

doi: 10.3389/fimmu.2019.00002

Juni 2019:

Wege AK, O, Brockhoff G. et al.: "HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women." Breast Cancer Res. 2018 Nov 20;20(1):139.

doi: 10.1186/s13058-018-1072-1.

Mai 2019:

Pabel, S. et al.: "Empagliflozin directly improves diastolic function in human heart failure." European Journal of Heart Failure, Oct. 2018.

doi.org/10.1002/ejhf.1328

April 2019:

Poeppl TB, Donges MR, Mokros A, Rupprecht R, Fox PT, Laird AR, Bzdok D, Langguth B, Eickhoff SB.: "A view behind the mask of sanity: meta-analysis of aberrant brain activity in psychopaths." Molecular Psychiatryvolume 24, pages463–470 (2019).

doi: https://doi.org/10.1038/s41380-018-0122-5

März 2019:

Paloma Riquelme, James A. Hutchinson et al.
"TIGIT + iTregs elicited by human regulatory macrophages control T cell immunity." Nature Communications Volume 9, Article Number: 2858 (2018).

doi.org/10.1093/cvr/cvy152

Februar 2019:

Sossalla, S. et al.
"Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart." Cardiovascular Research, Volume 114, Issue 13, 1 November 2018.

doi.org/10.1093/cvr/cvy152

Januar 2019:

Winkler, T.;  Heid, I. et al.
"A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications." Nat Commun. 2018 May 16;9(1):1946.

doi: 10.1038/s41467-018-04124-9.

Dezember 2018:

Buchtler, S. et al.
"Cellular Origin and Functional Relevance of Collagen I Production in the Kidney". JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; Published online: May 18, 2018.

Doi: 10.1681/ASN.2018020138

November 2018:

Lebek, S. et al.
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity. J Mol Cell Cardiol. 2018; 118: 159-168;

Doi: 10.1016/j.yjmcc.2018.03.020

Mycielska, M. et al.
Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo. Cancer Res May 15 2018 78 (10) 2513-2523;

DOI: 10. 1158/0008-5472.CAN-17-2959

August 2018:

Zellner, J. et al.
Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation. Am J Sports Med. 2017 Nov;45(13):3069-3080.

doi: 10.1177/0363546517717679.

Juli 2018 
 

Dr. med. Julian Mustroph & Dr. med. Stefan Neef
Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S.
"SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure” J Mol Cell Cardiol. 2018 Mar;116:81-90

https://doi.org/10.1016/j.yjmcc.2018.02.002

Juni 2018 

M. Werner-Klein, S. Scheitler, M. Hoffmann et. al
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nature Communications 9, Article number: 595 (2018).

Doi: 10.1038/s41467-017-02674-y

Mai 2018 

Neef, S. et al.
Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor
J Mol Cell Cardiol (2018) 115:73-81. doi:

https://doi.org/10.1016/j.yjmcc.2017.12.015

April 2018 

Hoffmann M., Schamberger Th., et.al
Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer
International Journal of Cancer 2018, Vol. 142, Issue 4

https://doi.org/10.1002/ijc.31108

Januar 2018 

Bittner S, Knoll G, Ehrenschwender M.,
Hyperosmotic stress enhances cytotoxicity of SMAC mimetics.
Cell Death & Disease. 2017;8(8):e2967-.

doi:10.1038/cddis.2017.355. 

Dezember 2017 

Can Martin Sag, Moritz Schnelle, Juqian Zhang, Colin E. Murdoch, Sabine Kossmann, Andrea Protti, Celio X. C. Santos, Greta J. Sawyer, Xiaohong Zhang, Heloise Mongue-Din, Daniel A. Richards, Alison C. Brewer, Oleksandra Prysyazhna, Lars S. Maier, Philip Wenzel, Philip J. Eaton, Ajay M. Shah
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell Nox2 on Blood Pressure
Circulation. 2017;CIRCULATIONAHA.116.023877
Published online: March 15, 2017

doi.org/10.1161/circulationaha.116.023877

November 2017

Koller M, Hjermstad MJ, Tomaszewski KA, Tomaszewska IM, Hornslien K, Harle A, Arraras JI, Morag O, Pompili C, Ioannidis G, Georgiou M, Navarra C, Chie WC, Johnson CD, Himpel A, Schulz C, Bohrer T, Janssens A, Kulis D, Bottomley A; EORTC Quality of Life Group; EORTC Lung Cancer Group; European Society of Thoracic Surgeons. An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients.
Ann Oncol. 2017 Aug 22.

doi: 10.1093/annonc/mdx453. [Epub ahead of print] PubMed PMID: 28945875

Oktober 2017

Neef, S. et al.
Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.
Basic Research in Cardiology (2017) 112: 45. doi: 10.1007/s00395-017-0637-y
Scientific Reports 7:41521

September 2017

Linda T. Betz, Andreas Mühlberger, Berthold Langguth & Martin Schecklmann
Stress Reactivity in Chronic Tinnitus
Scientific Reports 7:41521

doi: 10.1038/srep41521

Wege AK, Weber F, Kroemer A, Ortmann O, Nimmerjahn F, Brockhoff G.
IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget. 2017 Jan 10;8(2):2731-2744.
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=13159&pubmed-linkout=1

Juni 2017

Bittner, S., Knoll, G. & Ehrenschwender, M.
Death receptor 3 mediates necroptotic cell death. Cellular and Molecular Life Sciences (2017) 74: 543. doi:10.1007/s00018-016-2355-2 
https://link.springer.com/article/10.1007/s00018-016-2355-2#Abs1

Mai 2017
Hosseini H, Obradović MM, Hoffmann M, Harper KL, Sosa MS, Werner-Klein M, Nanduri LK1, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G, Gužvić M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf AD, Taran FA, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA3, Klein CA.
Early dissemination seeds metastasis in breast cancer.
Nature. 2016 Dec 14. doi: 10.1038/nature20785.
http://www.nature.com/nature/journal/v540/n7634/full/nature20785.html

April 2017

Almut Brand, Katrin Singer, Gudrun E. Koehl, Marlene Kolitzus, Gabriele Schoenhammer, Annette Thiel, Carina Matos, Christina Bruss, Sebastian Klobuch, Katrin Peter... Marina Kreutz.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Cell Metabolism 24 (November 8, 2016, 657–671). 2016 Elsevier Inc.
doi: 10.1016/j.cmet.2016.08.011
https://www.ncbi.nlm.nih.gov/pubmed/27641098 

März 2017

Pylypenko O., Welz T., Tittel J., Kollmar M., Chardon F., Malherbe G., Weiss S., Michel C.I.L., Samol-Wolf A., Grasskamp A.T., Hume A., Goud B., Baron B., England P., Titus M.A., Schwille P., Weidemann T., Houdusse A., Kerkhoff E. (2016) Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. eLife 5:e17523
https://elifesciences.org/content/5/e17523


Februar 2017

W. Herr, Y. Eichinger, J. Beshay, A. Bloetz, S. Vatter, C. Mirbeth, E. Distler, U.F. Hartwig, S. Thomas
HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell Transplantation.
Leukemia. 2016 Sep 2. doi: 10.1038/leu.2016.210
http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2016210a.html


Januar 2017

Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R.
Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.
Microbiome. 2016;4:28. doi:10.1186/s40168-016-0175-0.
http://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0175-0