Gezielte Immunmodulation in Krebs

2022
Basic Science Award at EBMT 2022 

2022 
Excellence Funding Programme for Established Scientists by German Cancer Aid 

2020  
Elected ASH Scientific Committee Member for Stem Cell Transplantation and Cellular Therapies (3-year term)

2018  
Admission into the EMBO Young Investigator Programme (supports the best young researchers in the life sciences in Europe and beyond).

2017 
Mechthild-Harf Research grant by DKMS

2016  
European Hematology Association (EHA) Research Grant

2013 
Feodor Lynen Research Fellowship for Experienced Researchers (Alexander von Humboldt-Foundation)

2010  
Walther-Schulz Research Award  

2009  
Vincenz-Czerny Research Award by the German society for Hematology and Oncology (DGHO) 

2006  
Kulturpreis Bayern by Bavarian State Ministry of Sciences, Research and the Arts and E.ON Bayern AG (for the best doctoral thesis of the LMU)

2004  
Harvard-Scholarship by the LMU-HMI-Alliance  

2003-2005  
Scholarship for gifted students of the Bayer Science and education Foundation 

2003  
Carl-Duisberg Scholarship 

1. Poeck, H., Wintges, A., Dahl, S., Bassermann, F., Haas, T., Heidegger, S. (2021). Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice. Eur J Immunol 51, 1531-1534.

2.  Heidegger S*^#, Wintges A *, Stritzke F, Bek S, Steiger K, Koenig PA, Göttert S, Engleitner T, Öllinger R, Nedelko T, Fischer JC, Makarov V, Winter C, Rad R, van den Brink MRM, Ruland J, Bassermann F, Chan TA, Haas T, Poeck H. (2019) RIG-I activation is critical for responsiveness to checkpoint blockade. Sci Immunol 4 , eaau8943.

3. Fischer JC, Bscheider M, Göttert S, Thiele Orberg E, Combs SE, Bassermann F, Heidegger S, Haas T, Poeck H. Type I interferon signaling before hematopoietic stem cell transplantation lowers donor T cell activation via reduced allogenicity of recipient cells. Sci Rep . 2019 Oct 18;9(1):14955.

4. Bek S, Stritzke F, Wintges A, Nedelko T, Böhmer D.F.R, Fischer JC, Haas T, Poeck H *^# & Simon Heidegger *^#. ( 2019). Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines. Oncoimmunology 8 , e1570779.

5. Heidegger S *^# , Kreppel D * , Bscheider M, Stritzke F, Nedelko T, Wintges A, Bek S,Fischer JC, Graalman T, Kalinke U, Bassermann F, Haas T, Poeck H. (2019). RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade. EBioMedicine 41 , 146-155.

6.  Fischer JC, Otten V, Drees C, Schmickl M, Heidegger S, Beyaert G, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H. (2017). NF- κ B regulator A20 modulates thymic regulatory T cell development; J Immunol 7, 2356-2365.

7. Fischer JC, M Bscheider, Gabriel Eisenkolb, Lin CC, 
 Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez K, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq R, Hanash A, Dudakov JA, Haas T, van den Brink MR *^# and Poeck H. (2017). RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci Transl Med 9 , eaag2513.

8. Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H*^#, Contassot E*^#, Zeiser R*^#. (2013). The Nlrp3 inflammasome regulates acute graft-versus-host disease. J Exp Med. 10, 1899-910.

9. Poeck H , Bscheider M, Gross O, Roth S, Finger K, Hannesschläger N, Schlee M, Rebsamen M, Rothenfusser S, Barchet W, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V and Ruland J . (2010). Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1beta production. Nat Immunol. 1 , 63-9.

10. Poeck H , Besch R, Maihoefer C, Renn M, Tormo D, Morskaya S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T & Hartmann G. (2008) . 5’-triphosphate siRNA: turning gene-silencing and RIG-I activation against melanoma. Nat Med. 11 , 1256-63.

• DFG (Collaborative Research Center (CRC 1371 (2019-2023; applied for 2^nd funding period; decision pending), PI, P05 " Role of innate immune signals and microbiota on intestinal epithelial regeneration in graft-versus host disease” ); https://www.sfb1371.tum.de/

• DFG (Collaborative Research Center (CRC 1335 (2018-2022; applied for 2^nd funding period; decision pending), PI, P14 "Mechanisms of immune evasion caused by aberrant innate nucleic acid receptor signaling in tumor cells and their tumor microenvironment); https://www.sfb1335.med.tum.de/en

• DFG (Collaborative Research Center (CRC TRR 221 (2022-2025 , PI, A08 "Timed Targeting of cGAS-STING in allo-HSCT” ) https://www.gvhgvl.de/en/

• Melanoma Research Alliance (2019-2022, PI, " Microbial metabolites in immunotherapy of malignant melanoma”, joint Project with PD Dr. Simon Heidegger), https://www.curemelanoma.org/research/grants/

• EMBO Young Investigator Program (2018-2023, PI, "Role of cytosolic nucleic Acid receptors in cancer immunotherapy”; travel-, meeting-, lab retreat-, sequencing, leadership and PhD course support) https://www.embo.org/funding/fellowships-grants-and-career-support/young-investigator-programme/

• Wilhelm-Sander Foundation (2021-2023, PI, " Bedeutung des intestinales Mikrobioms für Immunantwort und Prognose von Patienten mit Tumorerkrankungen und SARS-CoV-2 Infektion am Beispiel zweier Modellsituationen – ambulante Behandlung und stationäre Aufnahme") https://www.wilhelm-sander-stiftung.de /

• German Cancer Aid (2022-2027; PI, Targeted Modulation of Cancer Immunotherapies by Microbial-Derived Metabolites) https://www.presseportal.de/pm/116010/5124157

• Else Kröner-Research College Regensburg – Interdisciplinary Translational Immuno-Oncology (2020-2023; PI, "Role of innate immune signaling in epithelial regeneration”) https://www.ekfs.de/en/scientific-funding/currently-funded-projects/else-kroner-research-college-regensburg

• Bavarian State Ministry of Science and Art for the promotion of Corona research Projects (PI, "Microbiome and COVID-19”, 2021-2022)

• Chiara Suriano, PhD
• Christine-Heidrun Fooks-Kölbl
• Dhyani Shah, PhD
• Eva Herschberger
• Kaiji Fan, Postdoc
• Leonard Knödler
• Luisa Becker
• Maria Krieger
• Markus Perl
• Omer Khalid, PhD
• Sascha Göttert, PhD
• Sabrina Kunz